Hermes


Subject: Hermes
Solicitation Number: HR001124S0025
Notice Type: PRESOL
NAICS: 541714
Notice Published: 05-14-24
Response Due: 06-11-24

Agency: DEPT OF DEFENSE
Office: DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Contact: Dr. Shannon Greene This email address is being protected from spambots. You need JavaScript enabled to view it.
Office Address: ARLINGTON, VA 222032114


Related Notices:
        04-19-24 PRESOL


Click for official SAM (FBO) notice, additional information, and accompanying attachments

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to develop systemic drug delivery platforms for medical countermeasures (MCMs). The Hermes program is explicitly seeking transformative approaches enabling the development of delivery platforms with systemic biodistribution, exceptional endosomal escape efficiency, and minimal toxicity. Successful proposals will include a detailed description of the proposed delivery platform including 1) screening pipeline, 2) reporter systems for monitoring biodistribution and expression in animal models, 3) methods to monitor immunogenicity/toxicity, and 4) chosen therapeutic cargo and justification. Systemic delivery platforms developed under the Hermes effort will be transferred to U.S. Government stakeholders for further development.