Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)

Subject: Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines (THRIVE)
Solicitation Number: ARPA-H-SOL-25-122
Notice Type: SOLICIT
NAICS: 541714
Set-Aside: No Set aside used
Notice Published: 10-17-25
Response Due: 12-19-25

Agency: Department of Health and Human Services
Office: NATIONAL INSTITUTES OF HEALTH
Contact: THRIVE PROGRAM This email address is being protected from spambots. You need JavaScript enabled to view it.
Office Address: Washington, DC 20005
Place of Performance: Washington, DC 20005

Related Notices:

Click for official SAM (FBO) notice, additional information, and accompanying attachments

Amendment 2: Changes to the ISO The purpose of this amendment is to amend the THRIVE ISO. An updated version of the ISO and an updated version of the ISO with tracked changes are included as attachments. Changes to the ISO include: Cost share is now strongly encouraged instead of mandatory. Multi-party teaming arrangements are no longer required. ARPA-H's involvement with regulatory facilitation has been clarified. Please review the amended ISO for all changes. ---------------------------------------------------------------------------------------------------------------- Amendment 1: Added the Frequently Asked Questions (FAQ) to the list of attachments. ---------------------------------------------------------------------------------------------------------------- The Advanced Research Projects Agency for Health (ARPA-H) Treating Hereditary Rare diseases with In Vivo precision genetic mEdicines (THRIVE) program envisions a future where patients can opt for one-time therapeutic interventions designed to slow, reverse, or cure disease, harnessing revolutionary technologies and a rapidly evolving understanding of the genetic underpinnings of the biological processes that lead to disease. Interested parties are invited to review the attached THRIVE Innovative Solutions Opening (ISO) ARPA-H -SOL-25-122. For detailed information regarding Proposers' Day review Special Notice (SN) ARPA-H-SN-25-131. Solution summaries are due October 31, 2025, 11:59 PM ET. For more information about THRIVE, please visit:https://arpa-h.gov/explore-funding/programs/thrive